Severe Sepsis With Septic Shock

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Severe Sepsis With Septic Shock trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 8 trials

RecruitingNot Applicable

NCT03244293

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its u…

China20 participantsStarted 2014-01-01

Treatment: no intervention

RecruitingNot Applicable

NCT06809868

Role of Transposable Elements in Septic Immune Aging

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answ…

United States116 participantsStarted 2025-02-14

Treatment: RNA and DNA Sequencing

RecruitingNot Applicable

NCT07286643

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

* Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without system…

India140 participantsStarted 2026-01-01

Treatment: POCUS, Fixed Resuscitation Strategy based on Target MAP

RecruitingPhase 3

NCT07063095

A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patien…

The goal of this clinical trial is to : 1. Test whether the combination of CAZ±AVI and FOS leads to superior clinical outcomes in patients with severe suspecte…

Switzerland100 participantsStarted 2025-08-25

Treatment: Ceftazidime± avibactam with fosfomycin, Ceftazidime± avibactam with placebo

RecruitingPhase 3

NCT04750070

Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths. The coexistence of sepsis and…

Bangladesh135 participantsStarted 2021-08-17

Treatment: Blood and Dopamine, Blood and adrenaline

RecruitingNot Applicable

NCT04920565

Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surg…

Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterog…

Russia20 participantsStarted 2021-11-01

Treatment: hemoperfusion with polymyxin B

All recent trials (100 shown)

Active — Not RecruitingNot Applicable

NCT03901807

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic sep…

United States150 participantsStarted 2020-01-09

Treatment: Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge

TerminatedPhase 3

NCT01682590

I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)

The purpose of this multicentric, randomized controlled trial is to assess whether the timing of renal replacement therapy initiation (early vs delayed) has an…

France500 participantsStarted 2012-07

Treatment: Renal Remplacement Therapy

Severe Sepsis With Septic Shock

Trial phase breakdown

Trial status

Actively recruiting — 8 trials

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Role of Transposable Elements in Septic Immune Aging

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patien…

Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surg…

All recent trials (100 shown)

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)

Trial phase breakdown

Trial status

Actively recruiting — 8 trials

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Role of Transposable Elements in Septic Immune Aging

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patien…

Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surg…

All recent trials (100 shown)

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)

COrporeal Compression at the ONset of Severe Sepsis and Septic Shock

Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock

Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis

L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia

Citrulline and Arginase Activity in Severe Sepsis and Septic Shock

Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock

Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments

Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation

Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ven…

Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ven…

Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock

High-dose Intravenous Vitamin C in Patients With Septic Shock

Vitamin C & Thiamine to Treat Sepsis and Septic Shock

(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis

Blood Purification in Patients With Septic Shock

Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ven…