CompletedNot Applicable

Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock

China22 participantsStarted 2019-02-01

Plain-language summary

This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Septic shock
✓. A dose of norepinephrine (\>15ug/min)
✓. Age ≥18 and ≤80 years old
✓. Signing Informed Consent

Exclusion criteria

✕. Meet the inclusion criteria for more than 12 hours
✕. Clinician judges that corticosteroid therapy should not be used
✕. Pregnant
✕. Uncontrolled malignancy
✕. Glucocorticoid therapy was used within seven days before admission.
✕. Expected death within 24 hours
✕. The sublingual microcirculation cannot be measured

What they're measuring

Perfused vessel density (PVD)

Timeframe: 24 hours after treatment

Trial details

NCT IDNCT03821714

SponsorSoutheast University, China

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-01

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