CompletedPhase 2

Vitamin C & Thiamine to Treat Sepsis and Septic Shock

United States120 participantsStarted 2018-09-14

Plain-language summary

Investigators propose to investigate the use of IV vitamins B1 and C in a randomized, double-blinded, prospective trial to determine if these medications decrease mortality rates in patients with severe sepsis or septic shock.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓. Between the ages of 18 and 90 years old
✓. Have severe sepsis or septic shock. Severe sepsis and septic shock will be defined by the Surviving Sepsis 2012 guidelines.
✓. Weight more than 30 kg
✓. Full code

Exclusion criteria

✕. Not diagnosed with severe sepsis or septic shock
✕. Younger than 18 or older than 90 years old
✕. With a history of nephrolithiasis
✕. Who are pregnant
✕. Weigh less than 30 kg
✕. Not located in the ICU
✕. Do not resuscitate (DNR) or do not intubate (DNI), no escalation of care, or comfort measures only (CMO)
✕. Currently on dialysis

What they're measuring

Mortality Rates

Timeframe: From time of treatment to 30 days post hospital discharge, up to 87 days.

Trial details

NCT IDNCT03592277

SponsorTrinity Health Of New England

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-02-22

Results submitted2022-03-22

View on ClinicalTrials.gov More Sepsis trials