CompletedNot Applicable

Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock

Ireland100 participantsStarted 2021-09-01

Plain-language summary

The sublingual microcirculation is impaired in sepsis and septic shock. Sidestream dark field imaging technology has been developed into a clinical tool to help the clinician assess the microcirculation at the bedside. The ideal resuscitation fluid has not been identified. The investigators aim to use this new bedside technology to establish the microcirculation properties of two popular resuscitation fluids.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Sepsis; suspected source of infection, tachycardia, tachypneic, hyperlactatemia, hypotensive requiring vasopressors, febrile \>38.5degrees Celsius * Fluid responsive; pulse pressure variability \>10% or passive leg raise positive Exclusion Criteria: * Fluid overloaded; pulmonary oedema, significant peripheral oedema * Heart Failure, cardiogenic shock, recent MI * Receiving regular albumin 20%

What they're measuring

Change in Microcirculation parameters in response to a fluid bolus

Timeframe: Baseline at recruitment before fluid given, during bolus, after bolus: immediately after, 60 minutes after and 24 hours after to determine if immediate, delayed or sustained change in microcirculation parameters is influenced by fluid bolus

Trial details

NCT IDNCT05357339

SponsorRachael Cusack

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07-10

View on ClinicalTrials.gov More Sepsis, Severe trials