Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments

Inclusion Criteria: * Patient has a 'suspected infection': this requires the combination of antibiotic administration and body fluid cultures within the first 6 hours after Emergency Department presentation. * Patient has a NEWS score ≥ 5. Exclusion Criteria: * Patient (≥18 years old) or legally authorized representative didn't provide informed consent. Delayed informed consent can be applied in cases where the patient is critically ill and no LAR is available. * antibiotic administration as a single dose or as a prophylactic treatment. * antibiotics administered without an accompanying body fluid culture according to the timeframe (within 6 hours after emergency department presentation). * 'Do no intubate' or 'comfort measures only' status. * Failure to randomize within 6 hours after Emergency Department presentation. * Weight \< 45 kg. * Pregnant or breastfeeding. * Known allergy for Vitamin C. * Known history of oxalate nephropathy or hyperoxaluria. * Known history of glucose-6-phosphate dehydrogenase deficiency. * Known history of chronic iron overload due to iron storage and other diseases. * The patient is already on IV steroids for a reason other than septic shock. * Proven active COVID-19 infection (positive swab and/or CT scan positive for COVID-19 within 14 days prior to or at ED presentation). * Participation in an interventional trial with an investigational medicinal product (IMP) or device