Not Yet RecruitingNot Applicable

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

United States30 participantsStarted 2026-12

Plain-language summary

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults with severe sepsis or septic shock on mechanical ventilation * Enrolled in the initial six hours of ICU admission Exclusion Criteria: * Patients with withdrawal or hospice order. * Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission. * Patients with COPD. * Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

What they're measuring

Multi-organ failure

Timeframe: daily for 48 hours then weekly for 2 weeks.

Trial details

NCT IDNCT01315782

SponsorThe University of Texas Health Science Center, Houston

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12

Contact for this trial

Rosa M Estrada-Y-Martin, MD MSc

713-500-6830 rosa.m.estrada.y.martin@uth.tmc.edu

View on ClinicalTrials.gov More Sepsis trials