Tuberculosis, Meningeal

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Tuberculosis, Meningeal trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

RecruitingPhase 2

NCT05590455

Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis

Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis…

Brazil, Mozambique, Zambia130 participantsStarted 2023-04-11

Treatment: Adalimumab Injection

RecruitingPhase 2

NCT05383742

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard…

The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) vers…

Brazil, India, Kenya330 participantsStarted 2023-12-07

Treatment: Rifampicin (RIF), Isoniazid (INH)

RecruitingPhase 2

NCT06446245

Adjunctive Doxycycline for Central Nervous System Tuberculosis

Although tuberculosis is now considered a treatable disease, central nervous system tuberculosis (CNS-TB) when managed with the current standard-of-care (SOC),…

Indonesia, Malaysia, Singapore200 participantsStarted 2025-08-21

Treatment: Doxycycline, Placebo

RecruitingNot Applicable

NCT06135818

Same Day Diagnosis of Extrapulmonary TB (TB Serositis and TB Meningitis).

Extrapulmonary TB (EPTB) accounts for nearly 30% of TB cases in HIV endemic settings, such as South Africa. The diagnosis of extrapulmonary TB is complicated by…

South Africa, Zambia, Zimbabwe2,160 participantsStarted 2021-03-16

Treatment: IRISA-TB

All recent trials (31 shown)

Not Yet RecruitingPhase 2

NCT07227779

B-PaLMZ for TB Meningitis

This two-stage study will compare consented research participants with tuberculous meningitis receiving BPaLMZ to controls receiving SOC of rifampicin (R), ison…

United States, Uganda240 participantsStarted 2026-06-15

Treatment: BPaLMZ Regimen

Not Yet RecruitingPhase 2

NCT07350174

Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis

AlpE is a novel drug combination under development for the treatment of TB, with several positive attributes for TBM, including rapid bactericidal activity. The…

Location not specified64 participantsStarted 2026-03-30

Treatment: HRZE, HRZE plus Alpe375

Tuberculosis, Meningeal

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard…

Adjunctive Doxycycline for Central Nervous System Tuberculosis

Same Day Diagnosis of Extrapulmonary TB (TB Serositis and TB Meningitis).

All recent trials (31 shown)

B-PaLMZ for TB Meningitis

Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard…

Adjunctive Doxycycline for Central Nervous System Tuberculosis

Same Day Diagnosis of Extrapulmonary TB (TB Serositis and TB Meningitis).

All recent trials (31 shown)

B-PaLMZ for TB Meningitis

Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis

Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis

Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Menin…

Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis

Intrathecal Therapy for Adult Tuberculous Meningitis: Impact on Clinical Outcomes

Adjunctive Linezolid for the Treatment of Tuberculous Meningitis

Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)

Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis

Intensified Short Course Regimen for TBM in Adults

Pharmacokinetic Study of Linezolid for TB Meningitis

Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis (TBM) in Maharaj Nakorn Chiang Mai Hospital

Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes

Driving Reduced AIDS-associated Meningo-encephalitis Mortality

Optimizing Treatment to Improve TBM Outcomes in Children

Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM

Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis

Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis

Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis

High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study