A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis

Inclusion Criteria: * Male or female, aged 18 years or above. * Suspected TBM and anti-tuberculosis chemotherapy either planned or started * Less than 3 days of anti-tuberculosis chemotherapy taken for the current infection * Patient or representative (if the patient is unable) is willing and able to give informed consent for participation in the study. Exclusion Criteria: * HIV infection (negative rapid test or Elisa test is required) * Unlikely, for any reason, to be able to have an MRI brain scan within 5 days (120 hours) of randomisation * Known or suspected infection with multi-drug resistant tuberculosis (resistant to at least isoniazid and rifampicin) * Unable to take isoniazid, rifampicin, or pyrazinamide at recommended doses for any reason * History of diagnosed peptic ulceration or gastro-intestinal bleeding * Active gastro-intestinal bleeding is suspected * Taken \>1 dose of aspirin (at any dose) or any other non-steroidal anti-inflammatory drugs for any reason within 2 weeks of screening * Aspirin considered mandatory for any reason by the attending physician * Aspirin considered to be contraindicated for any reason by the attending physician * Pregnancy or breast feeding (negative urine pregnancy test for all females of child-bearing age) * Dexamethasone considered to be contraindicated for any reason by the attending physician * Any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because…