CompletedNot Applicable

Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis (TBM) in Maharaj Nakorn Chiang Mai Hospital

62 participantsStarted 2015-01-01

Plain-language summary

Early diagnosis and appropriate treatment of tuberculous meningitis (TBM) are crucial steps to reduce morbidity and mortality. The WHO recommended to use Xpert MTB/RIF assay to diagnose pulmonary TB, pediatrics TB, extra pulmonary TB and rifampicin resistance. However, the data of accuracy in diagnosis of TBM is still lacking. This study aimed to find out the diagnostic performance of Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis, especially in patients who presented with subacute lymphocytic meningitis.

Who can participate

Age range15 Years

SexALL

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Inclusion criteria

✓. Presence of meningitis symptoms and signs including one or more of the following: headache, irritability, vomiting, fever, neck stiff ness, convulsions, focal neurological deficits, altered consciousness, or lethargy at least 5 days prior to admission, plus
✓. CSF with abnormalities of at least two of these three characters;

Exclusion criteria

✕. Contraindicated in lumbar puncture
✕. Positive for cryptococcal antigen in the CSF.

What they're measuring

Detection of M. tuberculosis from CSF specimen

Timeframe: 2 years

Trial details

NCT IDNCT05781646

SponsorChiang Mai University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-03-30

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