Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes

Plain-language summary

The goal of this Diagnostic accuracy study is * To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and * To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical outcomes after completion of therapy * Secondary objectives * To study the proportion of patients having clinical or imaging features of spinal tubercular arachnoiditis * To study the factors determining outcomes in patients with spinal tubercular arachnoiditis * To study the treatment trends in patients with spinal tubercular arachnoiditis The investigators will include \[study Population\] Patients with chronic meningitis as per criteria listed below * Chronic meningitis : Case definition * Headache with or without fever, nuchal stiffness and systemic symptoms AND * CSF suggestive of meningitis Pleocytosis (\>20 cells per μL) with lymphocyte predominance (\>50%) OR Protein concentration greater than age-specific normal value; especially \>1•0 g/L OR Glucose concentration less than 60% of concentration in blood OR MRI suggestive of meningeal enhancement on contrast enhanced T1 sequences AND * Deemed by the treating physician that the syndrome is consistent with chronic meningitis * Patients who are positive for antibodies to HIV and pregnant females will also be included. * Willing to undergo periodic assessment clinically and with MRI as per clinical condition demands. The sensitivity and specificity of the finding of sulcal tuberculomas will be compared to the reference standard diagnostic criteria for the diagnosis of TB meningitis.

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