Small Intestine Bacterial Overgrowth

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Small Intestine Bacterial Overgrowth trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 16 trials

RecruitingPhase 2

NCT07451171

Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children

The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Ba…

Bangladesh60 participantsStarted 2026-04-18

Treatment: Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole

RecruitingPhase 1/2

NCT04353778

Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

The study team's prior research has shown that dysfunction of a specific nerve, called the vagus nerve, is associated with small intestinal bacterial overgrowth…

United States207 participantsStarted 2020-08-03

Treatment: Pyridostigmine, Placebos

RecruitingNot Applicable

NCT05976165

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.

United States50 participantsStarted 2023-11-17

Treatment: Breath Testing

RecruitingNot Applicable

NCT07145580

Combined Lactulose H2-breath Test With Abdominal Imaging

Hydrogen (H₂) breath tests serve several purposes. (i) detect malabsorption of carbohydrates such as lactose and fructose, (ii) measurement of oro-caecal transi…

Switzerland500 participantsStarted 2025-08-01

RecruitingPhase 1

NCT05967871

Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth

The objective of the study is to assess feasibility, and clinical efficacy of a novel Fecal Microbiota Transplantation protocol for the treatment of pediatric s…

Canada20 participantsStarted 2024-03-11

Treatment: Fecal Microbiota Transplant

RecruitingPhase 1

NCT06298409

Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®

We will sample intestinal microbiota using a microbiome sampling capsule in patients with Small Intestinal Bacterial Overgrowth (SIBO)

United States34 participantsStarted 2024-02-15

Treatment: CapScan collection capsule

All recent trials (81 shown)

Not Yet RecruitingNot Applicable

NCT07479238

Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy

Pancreatic exocrine insufficiency (PEI) results from reduced pancreatic enzyme secretion, leading to malabsorption, malnutrition, and impaired quality of life.…

Italy100 participantsStarted 2026-04-30

CompletedNot Applicable

NCT07122284

Gut Microbiome-Metabolome Profiling in H. Pylori-SIBO Comorbidity

Patients with concurrent Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO) represent a clinically challenging subgroup, often exper…

China42 participantsStarted 2024-01-31

Treatment: 13C-Urea Breath Test, Hydrogen-Methane Breath Test

Small Intestine Bacterial Overgrowth

Trial phase breakdown

Trial status

Actively recruiting — 16 trials

Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children

Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Combined Lactulose H2-breath Test With Abdominal Imaging

Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth

Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®

All recent trials (81 shown)

Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy

Gut Microbiome-Metabolome Profiling in H. Pylori-SIBO Comorbidity

Trial phase breakdown

Trial status

Actively recruiting — 16 trials

Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children

Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Combined Lactulose H2-breath Test With Abdominal Imaging

Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth

Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®

All recent trials (81 shown)

Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy

Gut Microbiome-Metabolome Profiling in H. Pylori-SIBO Comorbidity

The Low FODMAP Diet in Individuals With Small Intestinal Bacterial Overgrowth (SIBO)

Effect of Multispecies Probiotic Supplementation on the Efficacy of Rifaximin α Therapy in Patients With Small Intestina…

Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility

Small Intestinal Bacterial Overgrowth Obese

The Efficacy of Probiotics as an Adjunct to Treatment of SIBO With Rifaximin

Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorpti…

A Trial of a Multi-Component Nutritional Supplement in Hydrogen-Dominant Small Intestinal Bacterial Overgrowth

Rifaximin for Treatment of Bloating in Children and Adults With Cystic Fibrosis

High-fat Diet (HFD) and Small Intestinal Microbiome

Clinical Utility of Handheld Hydrogen Breathalyzer in Identification of Food Sensitivities (AIRE Study)

A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing

Small Intestinal Bacterial Overgrowth: A Prospective Registry

Methane and Hydrogen Breath Test for the Diagnosis of Small Intestinal Bacterial Overgrowth

Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Patients With Abdominal Distension

Treating Bacterial Overgrowth in Parkinson's Disease

Feasibility of a New Diagnostic Device to Assess Small Intestinal Dysbiosis in Routine Clinical Setting.

Therapeutic Effect of Olive Leaf Tea on SIBO

Clinical Study of Fecal Microbiota Transplantation in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)