High-fat Diet (HFD) and Small Intestinal Microbiome

Inclusion Criteria: * Informed Consent as documented by signature (Appendix Informed Consent Form) * Adults ≥18 years of age * BMI between 18.5 and 25 kg/m2 Exclusion Criteria: * Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product, * Define drugs not allowed during the study or for specific periods of time prior to the administration of the test dose, * Women who are pregnant or breast feeding, * Intention to become pregnant during the course of the study, * Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.), * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * inability or unwillingness to provide blood samples and tissue samples (biopsies), * Participants taking oral anticoagulant or with bleeding disorders who would be at much higher risk of bleeding after biopsy samples or who are contraindicated for an endoscopic examination, * Uncertain diagnosis, non-resident patients and patients unable to give info…