By InvitationNot Applicable

Small Intestinal Bacterial Overgrowth: A Prospective Registry

United States200 participantsStarted 2013-01-07

Plain-language summary

The purpose of this study is to investigate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients who will be undergoing an enteroscopy as an outpatient procedure with symptoms of functional dyspepsia. In addition, the investigators would like to identify the types of bacteria that are present in the small intestines in patients with SIBO and compare two different diagnostic tools: microbiologic culture and DNA sequencing of bacteria. The aim is to compare the microbiota between patients with and without the clinical complications of SIBO

Who can participate

Age range18 Years – 90 Years

SexALL

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Exclusion criteria

✕. Connective tissue disorder (scleroderma, polymyositis, mixed connective tissue disease, or systemic lupus
✕. Resection of ileocecal valve for any reason
✕. Chronic intestinal pseudo-obstruction
✕. Small bowel blind limb, diverticulum or fistula
✕. Surgery with decreased gastric acid exposure for small bowel a. Gastric surgery with vagotomy (Bilroth I, Bilroth II, vagotomy/pyloroplasty) or gastric bypass iv. Use of colon cleansing prep in the past 1 month v. Use of antibiotics in the past 30 days vi. Use of probiotics in the past 30 days vii. Contraindication for upper endoscopy for any reason viii. Prisoners ix. Pregnant x. Unable to give own informed

What they're measuring

To determine the predictors for SIBO in patients with functional dyspepsia, who do not have the established risk factors for SIBO

Timeframe: two years

Trial details

NCT IDNCT01822470

SponsorIndiana University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12

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