CompletedNot Applicable

Clinical Study of Fecal Microbiota Transplantation in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)

China66 participantsStarted 2022-09-10

Plain-language summary

Small intestinal bacterial overgrowth (SIBO) is defined as the presence of excessive numbers of bacteria in the small bowel causing gastrointestinal (GI) symptoms. These bacteria are usually coliforms, which are typically found in the colon and include predominantly Gram-negative aerobic and anaerobic species that ferment carbohydrates producing gas .Fecal Microbiota Transplantation (FMT) is a therapeutic method to transplant the microbiota from the feces of healthy people into the intestinal tract of patients. To explore the overall efficacy and safety of FMT in the treatment of SIBO.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with a positive breath test result upon initial admission. * Patients presenting with abdominal symptoms. * Patients who have stool and small intestinal fluid samples available before and after FMT. Exclusion Criteria: * Patients with gastrointestinal malignancies. * Patients with a history of gastrointestinal surgery. * Patients on long-term probiotic use. * Patients with a history of extensive antibiotic use.

What they're measuring

Incidence of adverse events (Assessing the safety of FMT in patients with SIBO)

Timeframe: 7 days, 1 month

Number of Patients with gastrointestinal symptom scores

Timeframe: 7 days, 1 month

Investigating the impact of FMT on the colonic and small intestinal microbiota.

Timeframe: 7 days, 1 month

Trial details

NCT IDNCT06162702

SponsorShanghai 10th People's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-10

View on ClinicalTrials.gov More Small Intestinal Bacterial Overgrowth trials