Severe Sepsis or Septic Shock

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Severe Sepsis or Septic Shock trials may be worth asking about

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

RecruitingNot Applicable

NCT07286643

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

* Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without system…

India140 participantsStarted 2026-01-01Updated 2025-12-16

Treatment: POCUS, Fixed Resuscitation Strategy based on Target MAP

RecruitingPhase 3

NCT04750070

Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths. The coexistence of sepsis and…

Bangladesh135 participantsStarted 2021-08-17Updated 2025-04-16

Treatment: Blood and Dopamine, Blood and adrenaline

RecruitingNot Applicable

NCT06145828

Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock

Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.

China60 participantsStarted 2023-10-23Updated 2023-11-24

Treatment: Cytokine Adsorption

All recent trials (40 shown)

CompletedNot Applicable

NCT03682003

Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?

Many biomarkers have been evaluated in sepsis, especially for prognostic purposes, but none has yet been shown to have sufficient sensitivity or specificity for…

France114 participantsStarted 2014-10-01Updated 2026-06-11

Treatment: blood diagnostic tests

CompletedPhase 4

NCT03068741

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensiv…

Canada2,061 participantsStarted 2020-03-23Updated 2026-04-20

Severe Sepsis or Septic Shock

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock

All recent trials (40 shown)

Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock

All recent trials (40 shown)

Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?

Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

COrporeal Compression at the ONset of Severe Sepsis and Septic Shock

Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock

Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock

Citrulline and Arginase Activity in Severe Sepsis and Septic Shock

Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments

(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis

Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis

Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis

A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.

Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock

What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin

The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis

GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults

Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG

Balanced Salt Solution VS. Normal Saline Solution in Septic Shock

IMproved PREdiction of Severe Sepsis in the Emergency Department

Jena Sepsis Registry

Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis