(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis

Inclusion Criteria: * Severe sepsis or septic shock * Onset of sepsis no longer than 24 hours * Increased risk of invasive candida infection with at least one of the following criteria: * total parenteral nutrition ≥48 hours * abdominal surgery within the last 7 days * antimicrobial therapy for at least 48 hours within the last 7 days * Acute or chronic renal failure with renal replacement therapy * Age ≥18 years * Informed consent of the patient or legal representative or delayed consent process is started if patient is incapable of giving informed consent and no legal representative is available. Exclusion Criteria: * Pregnant or lactating women * Ongoing invasive candida infection * systemic antifungal therapy * liver cirrhosis Child C * cardiopulmonary bypass within the last 4 weeks * treatment with immunoglobulins within the last 14 days * immunosuppression (solid organ transplantation, AISA, leukopenia) * participation in another intervention study * no commitment to full therapy (i.e. DNR order) * Infauste Prognose aufgrund von Nebenerkrankungen * kin to or colleague of study personnel