Refractory Gastroesophageal Reflux Disease

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Refractory Gastroesophageal Reflux Disease trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

RecruitingNot Applicable

NCT04699591

Compassionate Use of Domperidone for Refractory Gastroparesis

The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesop…

United States20 participantsStarted 2013-04

Treatment: Domperidone

RecruitingPhase 2

NCT05110144

Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough

This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory…

United States50 participantsStarted 2021-11-01

Treatment: Duloxetine 30 MG, Duloxetine 60 MG

All recent trials (29 shown)

By InvitationNot Applicable

NCT07437768

Vonoprazan Test for PPI Refractory GERD

Among patients suffering from gastroesophageal reflux disease (GERD) symptoms, esophageal pH monitoring and the assessment of symptom-reflux correlation can ide…

Taiwan100 participantsStarted 2025-12-24

Treatment: Patients received a 4-week treatment of vonoprazan 20 mg once daily (VOCINTI®)

Not Yet RecruitingPhase 2

NCT06704100

Oral Fosamprenavir + Sodium Alginate for GERD

The goal of this clinical trial is to learn if study drug Fosamprenavir-Sodium Alginate (FOS-SA) administered orally improves symptoms for Proton Pump Inhibitor…

United States60 participantsStarted 2026-03-01

Treatment: Fosamprenavir Calcium & Sodium Alginate, Placebo

Refractory Gastroesophageal Reflux Disease

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

Compassionate Use of Domperidone for Refractory Gastroparesis

Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough

All recent trials (29 shown)

Vonoprazan Test for PPI Refractory GERD

Oral Fosamprenavir + Sodium Alginate for GERD

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

Compassionate Use of Domperidone for Refractory Gastroparesis

Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough

All recent trials (29 shown)

Vonoprazan Test for PPI Refractory GERD

Oral Fosamprenavir + Sodium Alginate for GERD

Endoscopic Cardial Constriction Ligation (ECCL) for Refractory GERD Using a Disposable Endoscope

PPI Refractory - GERD Mechanisms in Systemic Sclerosis

Role of ARMA in Selective Subset of Refractory GERD Patients.

FODMAPs and Refractory GERD

Effect of MIST on Esophageal Sensitivity: Pilot Study

Anti-Reflux Mucosectomy in the Treatment of Refractory Gastro-esophageal Reflux

Gastric Neuromuscular Function in GERD

ARMA (Antireflux Mucosa Ablation) in Patients With Chronic Refractory Reflux Disease

Effect of MIST on Esophageal Sensitivity in Patients With rGERD

Jejunal Feeding Via Gastrojejunal Tube in Refractory Gastroesophageal Reflux

Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy

An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD Patients

Fexofenadine Use in Gastroesophageal Reflux Symptoms

The EndoGastric Solutions TEMPO Trial

A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump…

Prucalopride Treatment for Refractory Gastro-esophageal Reflux Disease

Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)

Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD)