Stopped: The study was terminated due to insufficient evidence for Fexofenadine efficacy to treat GERD symptoms after the interim analysis.
The investigators wish to study the effectiveness of Fexofenadine (an over the counter allergy pill) for the treatment of gastroesophageal reflux symptoms in patients who still have symptoms despite being on a proton pump inhibitor. The investigators will do this by giving participants both Fexofenadine (an H1 blocker) for 2 weeks and placebo (sugar pill) for 2 weeks. The participants will not know which drug they are getting at a particular time. This will help the investigators better assess the true effectiveness of Fexofenadine.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Mean Percent of Days With Reflux
Timeframe: 2 weeks per treatment
Mean Number of Reflux Episodes Per Day
Timeframe: 2 weeks per treatment
Mean GERD-HRQL Questionnaire Score
Timeframe: 2 weeks per treatment
Mean Symptom Severity Score
Timeframe: 2 weeks per treatment
Mean Rescue Medications Per Day
Timeframe: 2 weeks per treatment