Primary Sjogren's Disease

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Primary Sjogren's Disease trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

RecruitingPhase 2

NCT06979531

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic D…

This is a Phase 2b, multicenter, randomized, double-blinded, placebo-controlled study to assess the efficacy and safety of IMVT-1402 in adult participants with…

United States180 participantsStarted 2025-06-30

Treatment: IMVT-1402, Placebo

RecruitingNot Applicable

NCT03003572

Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity

Primary Sjögren's syndrome (pSS) can affect various organs, sometimes leads to life-threatening conditions and is always responsible for a decreased quality of…

France185 participantsStarted 2018-03-27

Treatment: Blood samples

RecruitingPhase 3

NCT07404865

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease (UPSTREAM SjD)

United States250 participantsStarted 2026-02-26

Treatment: Telitacicept, Placebo

RecruitingPhase 2

NCT07281456

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

Background: Sjogren disease is an autoimmune disease - that is, a disease that causes the body's immune system to attack its own organs and tissues. Sjogren di…

United States60 participantsStarted 2025-12-18

Treatment: Tofacitinib

RecruitingPhase 1/2

NCT06947473

Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.

This is a single-center, open-label, non-randomized, single-arm clinical trial. Patients with refractory lupus neritis (SLE-LN), systemic sclerosis (SSc), and p…

China45 participantsStarted 2026-03-18

Treatment: umbilical cord blood CD19-BCMA CAR-T cells infusion

RecruitingPhase 4

NCT07153276

TREATMENT OF VAGINAL DRYNESS IN SJÖGREN'S DISEASE WITH CO2-LASER VERSUS TOPICAL PROMESTRIENE

Sjögren's disease (SjD) is a chronic, immune-mediated, systemic inflammatory disease characterized mainly by involvement of the salivary and lacrimal glands, ca…

Brazil60 participantsStarted 2026-02-27

Treatment: Fractional CO2 laser (vaginal), Promestriene Vaginal

All recent trials (76 shown)

Active — Not RecruitingNot Applicable

NCT03711214

Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome

Primary Sjögren's syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome. p…

Brazil80 participantsStarted 2018-12-01

Treatment: Periodontal scaling

CompletedNot Applicable

NCT03157011

Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome

the investigators propose to carry out a prospective study consisting of a systematic research of digestive symptoms in patients with SGSp with the validated Gl…

France151 participantsStarted 2017-07-17

Treatment: Global symptom score (GSS) questionary

Primary Sjogren's Disease

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic D…

Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.

TREATMENT OF VAGINAL DRYNESS IN SJÖGREN'S DISEASE WITH CO2-LASER VERSUS TOPICAL PROMESTRIENE

All recent trials (76 shown)

Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome

Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic D…

Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.

TREATMENT OF VAGINAL DRYNESS IN SJÖGREN'S DISEASE WITH CO2-LASER VERSUS TOPICAL PROMESTRIENE

All recent trials (76 shown)

Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome

Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome

A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome

Aerobic Exercise in Primary Sjögren's Syndrome

Managed Access Programs for VAY736, Ianalumab

Efficacy and Safety of Baricitinib in Sjogren's Syndrome

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome

Investigation of the Effectiveness of Cognitive Exercise Therapy Approach in Patients With Primary Sjögren's Syndrome

Temporomandibular Joint Dysfunction in Sjögren's Syndrome

"Validity and Reliability of Pelvic Floor Distress Inventory-20 in Primary Sjögren's Syndrome"

A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)

Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS)

Quantification and Characterization of Circulating Epithelial and Endothelial Cells in Gougerot-Sjögren Syndrome, Compar…

"Core Stabilization Strenght and Pelvic Floor Functions in Primary Sjogren's"

Ro60 Expression in Macrophages in Sjogren's Disease

The Role of Central Sensitization on Biopsychosocial Factors in Primary Sjögren's Syndrome

N-acetylcysteine for Primary Sjögren's Syndrome

Assessing the Efficacy of a Carbamide Peroxide Mouthwash for Oral Wound Healing, Oral Hygiene and Xerostomia Relief

Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases

Efficacy and Safety of S95011 in Primary Sjögren's Syndrome Patients