Perimenopausal Depression

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Perimenopausal Depression trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

RecruitingPhase 4

NCT05282277

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function us…

United States103 participantsStarted 2022-04-20

Treatment: Transdermal Estradiol, Micronized Progesterone

RecruitingNot Applicable

NCT07135232

The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.

The aim of this clinical trial is to determine if resistance training and a newly developed plant-based nutritional supplement can improve the symptoms and musc…

United Kingdom72 participantsStarted 2026-03-01

Treatment: Sarmentosin - L- theanine, Resistance Training

RecruitingNot Applicable

NCT07481513

Impact of Intermittent Fasting on the Mental Health of Perimenopausal Women

This study will explore how intermittent fasting (specifically the 16/8 method) affects the mental health of women who are in the perimenopause stage. This life…

Lebanon140 participantsStarted 2025-09-23

Treatment: Intermittent fasting (16/8)

RecruitingNot Applicable

NCT07413705

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and…

The goal of this clinical trial is to evaluate if the combined treatment with EXOMIND (BTL-699-2) and EMSELLA (HPM-6000UF) devices is able to improve depressive…

United States, Canada60 participantsStarted 2025-11-20

Treatment: EXOMIND (BTL-699-2) Active Treatment, EMSELLA (HPM-6000UF) ActiveTreatment

RecruitingNot Applicable

NCT07022925

A Trial to Investigate the Accuracy of a Wearable Device in Collecting Data Related to Perimenopausal Symptoms in Women

The goal of this observational study is to investigate the accuracy of the device in characterizing perimenopausal and menopausal symptoms including vasomotor s…

Canada110 participantsStarted 2025-07-04

All recent trials (29 shown)

Not Yet RecruitingNot Applicable

NCT07533097

The Effect of Cold Packs on Hot Flushes and Depression in Women Going Through the Climacteric Period

This study is planned as a pre-post test, randomised controlled, experimental trial designed to determine the effect of applying a cold gel pack to the Sanyinji…

Turkey (Türkiye)80 participantsStarted 2026-04-13

Treatment: Cold gel packs application

By InvitationNot Applicable

NCT07511660

Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)

This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as f…

Mexico12 participantsStarted 2026-06-01

Perimenopausal Depression

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.

Impact of Intermittent Fasting on the Mental Health of Perimenopausal Women

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and…

A Trial to Investigate the Accuracy of a Wearable Device in Collecting Data Related to Perimenopausal Symptoms in Women

All recent trials (29 shown)

The Effect of Cold Packs on Hot Flushes and Depression in Women Going Through the Climacteric Period

Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.

Impact of Intermittent Fasting on the Mental Health of Perimenopausal Women

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and…

A Trial to Investigate the Accuracy of a Wearable Device in Collecting Data Related to Perimenopausal Symptoms in Women

All recent trials (29 shown)

The Effect of Cold Packs on Hot Flushes and Depression in Women Going Through the Climacteric Period

Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)

Effects of Jin Shin Jyutsu-Based Hand Application on Quality of Life and Psychosocial Status in Perimenopausal Women

Transcranial Electrical Stimulation for Noninvasive Study of Menopausal/Perimenopausal Symptoms

A Neurosteroid Intervention for Menopausal and Perimenopausal Depression

Study on Allopregnanolone and Depression in Perimenopausal Women

Estrogen Receptor Beta and Mood

Whole Body Hyperthermia Registry Study

Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"

Probiotics Therapy of Mood Disorders

Testing the Efficacy of Mindfulness-based Stress Reduction in the Prevention of Perimenopausal Depression

Estrogen and Perimenopausal Depression

Progesterone for Perimenopausal Night Sweats

The Effects of Estrogen Withdrawal on Mood Symptoms in Women

Perimenopausal Effects of Estradiol on Reward Responsiveness

Perimenopausal Estrogen Replacement Therapy Study

Raloxifene and Rimostil for Perimenopause-Related Depression

Effectiveness and Safety of Electro-acupuncture for Mild-to-moderate Perimenopausal Depression

Investigation of Tibolone and Escitalopram in Perimenopausal Depression

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia