Perimenopausal Effects of Estradiol on Reward Responsiveness

Exclusion criteria

• ✕. MDD Group Eligibility Criterion: current diagnosis of MDD with an onset associated with menstrual cycle irregularity, and no history of psychiatric illness during the 2 years before the onset of the current depressive episode as determined by the Structured Clinical Interview for DSM-IV-TR (Diagnostic and Statistical Manual-4-Text Revision) for Axis I Disorders (SCID);
• ✕. Control Group Eligibility Criterion: absence of any past or present psychiatric disorder as assessed by the SCID.
• ✕. current medication use (i.e., psychotropics, anti-hypertensives, statins, hormonal preparations, or frequent use of anti-inflammatory agents (\> 10 times/month)). Women will be allowed to enroll who take medications without known mood effects (e.g. stable thyroid hormone replacement and occasional (\< 5 times/month) use of Ambien)\*;
• ✕. pregnant, breastfeeding or trying to conceive;
• ✕. FMP more than 12 months prior to enrollment;
• ✕. history of undiagnosed vaginal bleeding;
• ✕. undiagnosed enlargement of the ovaries;
• ✕. polycystic ovary syndrome;