Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"

Exclusion criteria

• ✕. current medication use (i.e., psychotropics, anti-hypertensives, statins, hormonal preparations, or frequent use of anti-inflammatory agents (\> 10 times/month)). Women will be allowed to enroll who take medications without known mood effects (e.g. stable thyroid hormone replacement and occasional (\< 5 times/month) use of Ambien);
• ✕. pregnant, breastfeeding or trying to conceive;
• ✕. LMP more than 12 months prior to enrollment;
• ✕. history of undiagnosed vaginal bleeding;
• ✕. undiagnosed enlargement of the ovaries;
• ✕. polycystic ovary syndrome;
• ✕. history of breast or ovarian cancer;
• ✕. first degree relative with ovarian cancer;