Amphetamine Use Disorders

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Amphetamine Use Disorders trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

RecruitingPhase 2

NCT06788587

Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder

Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psyc…

Canada80 participantsStarted 2025-07-18

Treatment: LDX-01 plus TAU, Placebo plus TAU

RecruitingEarly Phase 1

NCT05011760

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in sub…

United States30 participantsStarted 2021-01-31

Treatment: Baseline [C-11]NPA PET Scan, d-amphetamine

RecruitingPhase 2

NCT05790239

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low…

United States40 participantsStarted 2025-03-01

Treatment: 3,4-methylenedioxymethamphetamine, d-amphetamine

RecruitingNot Applicable

NCT06701487

Role of Pavlovian Mechanisms for Control Over Substance Use

During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, gen…

Germany200 participantsStarted 2024-08-05

Treatment: fMRI imaging (BOLD), sMRI (structure)

RecruitingNot Applicable

NCT06457243

Closed-loop cTBS for the Core Clinical Features of Methamphetamine Use Disorder

Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop continuous Theta-burst Stimulation (cTBS) b…

China30 participantsStarted 2024-08

Treatment: Closed-loop cTBS stimulation based on addiction induced states

All recent trials (41 shown)

Active — Not RecruitingPhase 1/2

NCT04982796

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

This is a proof-of-concept randomized clinical trial of psilocybin-enhanced psychotherapy versus treatment-as-usual among individuals being treated for methamph…

United States30 participantsStarted 2022-07-07

Treatment: Psilocybin, Treatment-as-usual

Not Yet RecruitingPhase 2

NCT05529927

Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder

In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment…

Location not specified204 participantsStarted 2026-05

Treatment: Sustained-release Dexamphetamine, Placebo

Amphetamine Use Disorders

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Role of Pavlovian Mechanisms for Control Over Substance Use

Closed-loop cTBS for the Core Clinical Features of Methamphetamine Use Disorder

All recent trials (41 shown)

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Role of Pavlovian Mechanisms for Control Over Substance Use

Closed-loop cTBS for the Core Clinical Features of Methamphetamine Use Disorder

All recent trials (41 shown)

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder

tTIS Targeted of the Striatum as an Intervention for MUD Patients

Individualized Neuromodulation for the Core Clinical Features of Drug Addiction

Closed-loop tACS Modulation for the Core Clinical Features of Drug Addiction

Effects of Repetitive Transcranial Magnetic Stimulations in Patients With Amphetamine Use Disorders

The Norwegian Addiction, Pain and Trauma Study

Treatment Effect of Cross-frequency Transcranial Alternating Current Stimulation on the MUD

Floatation-REST in Methamphetamine Use Disorder: A Pilot Study

Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder

Repetitive Transcranial Magnetic Stimulation in Amphetamine Addiction

Change the Cycle: An RCT to Prevent Injection Initiation

Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers

Use of Amphetamine-type Stimulants & Its Relationship With HIV Incidence and Antiretroviral Adherence Among MSM and TG

Robot-Assisted Intelligent Rehabilitation Treatment for Methamphetamine Use Disorders.

Amphetamine Induced Adult Respiratory Distress Syndrome

Non-invasive Brain Stimulation in Patients With Methamphetamine Use Disorder

CDP-choline Treatment in ATS Users

Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorder

Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.