Individualized Neuromodulation for the Core Clinical Features of Drug Addiction (NCT06165198) | Clinical Trial Compass
CompletedNot Applicable
Individualized Neuromodulation for the Core Clinical Features of Drug Addiction
China9 participantsStarted 2023-09-25
Plain-language summary
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy with traditional open-loop tACS methods.
Who can participate
Age range18 Years – 45 Years
SexALL
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Inclusion Criteria:
* Individuals aged between 18 and 45 years, irrespective of gender, having completed a minimum of 9 years of education and capable of effectively cooperating in questionnaire evaluations.
* Meet the diagnostic criteria set forth by the DSM-V concerning the severity of amphetamine-type substance addiction.
* A history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use being at least once per week.
* Consent to actively cooperate in the completion of subsequent follow-up assessments.
Exclusion Criteria:
* Severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an IQ score less than 70.
* A diagnosis of schizophrenia or other severe mental illnesses as per the DSM-5 criteria.
* Abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years.
* Severe organic diseases that might compromise study participation.
* Contraindications to tACS, such as a history of epileptic seizures or the presence of metallic implants in proximity to the head.
What they're measuring
1
Stop-signal task
Timeframe: through study completion, an average of 1 month