[C-11]NPA PET-amphetamine in Cocaine Use Disorders

Inclusion criteria

• ✓. Males or females between 18 and 55 years old
• ✓. Fulfil DSM-5 criteria for cocaine use disorder
• ✓. No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
• ✓. No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, and MDMA as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991);
• ✓. Not currently on prescription medical or psychotropic medications
• ✓. No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
• ✓. Not currently pregnant or breastfeeding
• ✓. No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines