Closed-loop tACS Modulation for the Core Clinical Features of Drug Addiction

Inclusion Criteria: Individuals aged between 18 and 45 years, irrespective of gender, having completed a minimum of 9 years of education and capable of effectively cooperating in questionnaire evaluations. Meet the diagnostic criteria set forth by the DSM-V concerning the severity of amphetamine-type substance addiction. A history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use being at least once per week. Consent to actively cooperate in the completion of subsequent follow-up assessments. Exclusion Criteria: Severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an IQ score less than 70. A diagnosis of schizophrenia or other severe mental illnesses as per the DSM-5 criteria. Abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years. Severe organic diseases that might compromise study participation. Contraindications to tACS, such as a history of epileptic seizures or the presence of metallic implants in proximity to the head.