Treponema Pallidum

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Treponema Pallidum trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 24 trials

RecruitingNot Applicable

NCT06645106

Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Departm…

The purpose of this study is to offer routine lab-based and rapid point of care (POC) syphilis diagnostic testing in the emergency department (ED) and obstetric…

United States1,500 participantsStarted 2025-02-04

Treatment: Rapid Point of Care (POC) Syphilis testing

RecruitingNot Applicable

NCT06428643

A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities

This study includes testing for four STIs (chlamydia, gonorrhea, syphilis, and HIV) at no cost. If positive, individual subjects will also be counseled and offe…

United States2,322 participantsStarted 2025-08-14

Treatment: Chlamydia, gonorrhea, syphilis, and HIV screening

RecruitingPhase 3

NCT04958122

Cefixime Clinical Trial

This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.

United States400 participantsStarted 2021-06-20

Treatment: Cefixime 400mg, benzathine penicillin

RecruitingNot Applicable

NCT07300254

Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis:…

How syphilis is transmitted between sexual partners is unclear. Asymptomatic detection i.e. detection of syphilis bacteria (Tp) from anatomical sites without le…

Australia, China, South Africa480 participantsStarted 2025-12-02

Treatment: No Intervention: Observational Cohort

RecruitingNot Applicable

NCT07500415

Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro

The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs…

Brazil200 participantsStarted 2025-10-28

Treatment: Doxycycline

RecruitingNot Applicable

NCT07207876

Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

IMPAACT 2044 is a study to characterize the pharmacokinetics (PK) and safety of ceftriaxone and benzathine penicillin G during pregnancy. Up to 78 pregnant wome…

United States110 participantsStarted 2026-02-16

Treatment: Ceftriaxon, Benzathine penicillin G

All recent trials (100 shown)

Not Yet RecruitingNot Applicable

NCT07568171

Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics

Congenital syphilis in newborns requires intravenous antibiotic therapy, making reliable peripheral venous access essential. However, high rates of catheter fai…

Location not specified104 participantsStarted 2026-05

Treatment: Ultrasound-Guided Long Peripheral Intravenous Catheter, Short Peripheral Intravenous Catheter (Conventional Technique)

Active — Not RecruitingNot Applicable

NCT06927843

Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infe…

The goal of this observational study is to evaluate the sensitivity, specificity, and utility of the DPP® Syphilis Screen \& Confirm antibody point-of-care test…

Canada600 participantsStarted 2025-03-05

Treatment:

Treponema Pallidum

Trial phase breakdown

Trial status

Actively recruiting — 24 trials

Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Departm…

A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities

Cefixime Clinical Trial

Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis:…

Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro

Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

All recent trials (100 shown)

Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics

Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infe…

Trial phase breakdown

Trial status

Actively recruiting — 24 trials

Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Departm…

A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities

Cefixime Clinical Trial

Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis:…

Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro

Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

All recent trials (100 shown)

Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics

Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infe…

Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans

Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)

Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland

Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline H…

Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting

Linezolid for Syphilis Pilot Study

Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates

Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline

Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington

MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Congo

Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT

Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

Improving Maternal and Child Health Through Point-of-care STI Testing

Integrating Mental Health Into Neglected Tropical Disease Care in Ghana

Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)

Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care…

Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, Uganda