IMPAACT 2044 is a study to characterize the pharmacokinetics (PK) and safety of ceftriaxone and benzathine penicillin G during pregnancy. Up to 78 pregnant women receiving (1) ceftriaxone for indications other than syphilis or (2) benzathine penicillin G for treatment of syphilis from non-study clinical care providers will be enrolled at study sites located in the United States. Approximately 22 infants of pregnant participants receiving benzathine penicillin G will also be enrolled.
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Geometric mean area under the curve (AUC) during the dosing interval (AUC0-tau) in the first trimester trimester
Timeframe: First on-study dose through 24 hours
Geometric mean terminal elimination half-life (t1/2) in the first trimester
Timeframe: First on-study dose through 24 hours
Geometric mean trough concentration (Ctrough) in the first trimester
Timeframe: First on-study dose through 24 hours
Geometric mean AUC0-tau in the second trimester
Timeframe: First on-study dose through 24 hours
Geometric mean t1/2 in the second trimester
Timeframe: First on-study dose through 24 hours
Geometric mean Ctrough in the second trimester
Timeframe: First on-study dose through 24 hours
Geometric mean AUC0-tau in the third trimester
Timeframe: First on-study dose through 24 hours
Geometric mean t1/2 in the third trimester
Timeframe: First on-study dose through 24 hours
Geometric mean Ctrough in the third trimester
Timeframe: First on-study dose through 24 hours
Median maximum plasma concentration during the dose interval (Cmax) in the first trimester
Timeframe: First on-study dose through up to 24 hours
Median time to Cmax (Tmax) in the first trimester
Timeframe: First on-study dose through up to 24 hours
Median Cmax in the second trimester
Timeframe: First on-study dose through up to 24 hours
Median Tmax in the second trimester
Timeframe: First on-study dose through up to 24 hours
Median Cmax in the third trimester
Timeframe: First on-study dose through up to 24 hours
Median Tmax in the third trimester
Timeframe: First on-study dose through up to 24 hours
Geometric mean AUC at 7 days (AUC 0-7d) in the first trimester
Timeframe: First on-study dose through 7 days
Geometric mean AUC at 14 days (AUC0-14d) in the first trimester
Timeframe: First on-study dose through 14 days
Geometric mean plasma concentration at 2 hours (C2h) in the first trimester
Timeframe: 2 hours post-first on-study dose
Geometric mean plasma concentration at 24 hours (C24h) in the first trimester
Timeframe: 24 hours post-first on-study dose
Geometric mean plasma concentration at 4 days (C4d) in the first trimester
Timeframe: 4 days post-first on-study dose
Geometric mean plasma concentration at 7 days (C7d) in the first trimester
Timeframe: 7 days post-first on-study dose
Geometric mean plasma concentration at 14 days (C14d) in the first trimester
Timeframe: 14 days post-first on-study dose
Geometric mean AUC0-7d in the second trimester
Timeframe: First on-study dose through 7 days
Geometric mean AUC0-14d in the second trimester
Timeframe: First on-study dose through 14 days
Geometric mean C2h in the second trimester
Timeframe: 2 hours post-first on-study dose
Geometric mean C24h in the second trimester
Timeframe: 24 hours post-first on-study dose
Geometric mean C4d in the second trimester
Timeframe: 4 days post-first on-study dose
Geometric mean C7d in the second trimester
Timeframe: 7 days post-first on-study dose
Geometric mean C14d in the second trimester
Timeframe: 14 days post-first on-study dose
Geometric mean AUC0-7d in the third trimester
Timeframe: First on-study dose through 7 days
Geometric mean AUC0-14d in the third trimester
Timeframe: First on-study dose through 14 days
Geometric mean C2h in the third trimester
Timeframe: 2 hours post-first on-study dose
Geometric mean C24h in the third trimester
Timeframe: 24 hours post-first on-study dose
Geometric mean C4d in the third trimester
Timeframe: 4 days post-first on-study dose
Geometric mean C7d in the third trimester
Timeframe: 7 days post-first on-study dose
Geometric mean C14d in the third trimester
Timeframe: 14 days post-first on-study dose