Severe Traumatic Pain

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Severe Traumatic Pain trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

RecruitingPhase 3

NCT06917651

Management of Moderate to Severe Monotraumatic Pain With Sublingual Sufentanil in an Emergency Situation.

Pain is a common reason for emergency department (ED) visits. However, studies suggest that emergency physicians may not always provide optimal analgesic treatm…

France300 participantsStarted 2025-04-22

Treatment: sufentanil sublingual 30 mcg tablet, Standard of Care (SOC)

RecruitingNot Applicable

NCT07309874

Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches

Headaches such as tension-type, migraine, and cervicogenic (neck-related) headaches are among the most common and disabling conditions worldwide. and are often…

United States50 participantsStarted 2026-03-01

Treatment: Dry needling

RecruitingPhase 2

NCT05790239

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low…

United States40 participantsStarted 2025-03-01

Treatment: 3,4-methylenedioxymethamphetamine, d-amphetamine

RecruitingNot Applicable

NCT06070766

RIVER At Home Ketamine Protocols

Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suici…

United States50,000 participantsStarted 2023-10-01

Treatment: Ketamine

All recent trials (21 shown)

Not Yet RecruitingNot Applicable

NCT07475910

Venous Thromboembolism and Chronic Pain After Major Limb Trauma

Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoag…

Ukraine150 participantsStarted 2026-03-15

Active — Not RecruitingNot Applicable

NCT02337244

Zimmer POLAR Persona - TKA (EMEA Study)

The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona knee implants used in primar…

Austria, France, Germany777 participantsStarted 2013-11-18

Treatment: Zimmer Persona Total Knee System

Severe Traumatic Pain

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Management of Moderate to Severe Monotraumatic Pain With Sublingual Sufentanil in an Emergency Situation.

Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

RIVER At Home Ketamine Protocols

All recent trials (21 shown)

Venous Thromboembolism and Chronic Pain After Major Limb Trauma

Zimmer POLAR Persona - TKA (EMEA Study)

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Management of Moderate to Severe Monotraumatic Pain With Sublingual Sufentanil in an Emergency Situation.

Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

RIVER At Home Ketamine Protocols

All recent trials (21 shown)

Venous Thromboembolism and Chronic Pain After Major Limb Trauma

Zimmer POLAR Persona - TKA (EMEA Study)

Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting

Ketamine for Pain Control After Severe Traumatic Injury

Pain Multidisciplinar Intervention in Major Trauma Patients

The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study

Characterization & Treatment of Chronic Pain After Moderate to Severe TBI

A Biologic Joint Replacement Strategy for Knee Trauma and Post-Traumatic Osteoarthritis

Outcomes Mandate National Integration With Cannabis as Medicine

Cognitive-behavioral Therapy for Treatment of Post-traumatic Stress Disorder and Related Problems

Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries

Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Mor…

Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Re…

A Randomized, Double-blind Comparison of Morphine and Sufentanil for Prehospital Traumatic Severe Acute Pain

Intranasal Sufentanil Pain-management at Entrance of Emergency Department : Influence on Pain-relief Delay

A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Patients With Neuropathic Pain (Postherpet…

Morphine-Midazolam in Pre-hospital Traumatic Patients With Severe Acute Pain