Peptic Ulcer Bleeding

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Peptic Ulcer Bleeding trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 9 trials

RecruitingPhase 4

NCT05582174

PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers

Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1…

China594 participantsStarted 2023-05-18

Treatment: Vonoprazan, esomeprazole

RecruitingPhase 4

NCT04416581

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gast…

The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20…

South Korea3,320 participantsStarted 2021-05-12

Treatment: PPI, P-CAB 50

RecruitingNot Applicable

NCT06188585

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus convent…

United States278 participantsStarted 2024-06-21

Treatment: UI-EWD, Conventional therapy

RecruitingNot Applicable

NCT04394663

High Dose Oral Omeprazole in High Risk UGIB

Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI)…

Thailand128 participantsStarted 2020-10-01

Treatment: High-dose oral omeprazole, Standard IV PPI

RecruitingNot Applicable

NCT06543316

Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment

The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated…

United States100 participantsStarted 2025-03-04

Treatment: Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)

RecruitingNot Applicable

NCT06848400

Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios

The goal of this clinical trial is to evaluate the diagnostic accuracy of the AI-integrated Capsule Gastroscopy (ACG) system in simulated home-use conditions fo…

China482 participantsStarted 2025-03-03

Treatment: AI-integrated Capsule Gastroscopy (ACG) examination, Electronic gastroduodenoscopy (EGD) examination

All recent trials (100 shown)

Not Yet RecruitingPhase 4

NCT07312370

Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing

Endoscopic submucosal dissection (ESD) is an established treatment for early gastric cancer and precancerous lesions. Post-ESD artificial ulcers may lead to com…

China120 participantsStarted 2026-04-20

Treatment: Esomeprazole (Intravenous), Esomeprazole (Oral)

WithdrawnNot Applicable

NCT06196710

The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods

In managing bleeding gastroduodenal ulcers, endoscopic control of bleeding is the first line treatment-further bleeding after endoscopic hemostasis is associate…

Location not specified0Started 2025-10-01

Treatment: Over-the-scope Clips, Hemo-clipping

Peptic Ulcer Bleeding

Trial phase breakdown

Trial status

Actively recruiting — 9 trials

PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gast…

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

High Dose Oral Omeprazole in High Risk UGIB

Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment

Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios

All recent trials (100 shown)

Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing

The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods

Trial phase breakdown

Trial status

Actively recruiting — 9 trials

PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gast…

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

High Dose Oral Omeprazole in High Risk UGIB

Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment

Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios

All recent trials (100 shown)

Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing

The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods

Phase II Clinical Study of Vonorasan Fumarate Injection in the Treatment of Peptic Ulcer Bleeding

Hemostatic Forceps vs. Bipolar Electrocautery Probes for High-Risk Bleeding Gastroduodenal Ulcers

Anticoagulation With Enhanced Gastrointestinal Safety

Diagnostic Performance of CIM for Helicobacter Pylori Infection in Patients With Peptic Ulcer Bleeding

Efficacy of Vonoprazan Versus Intravenous Proton Pump Inhibitors for Prevention of Rebleeding in High Risk Peptic Ulcers…

Anticoagulation With Enhanced Gastrointestinal Safety (AEGIS) Trial

Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding

Over-the-scope Clip Versus Through-the-scope Clip for Endoscopic Hemostasis of High Risk Bleeding Peptic Ulcers

Diosmin as Adjuvant Therapy in Treatment of Non-bleeding Peptic Ulcer

Stress Ulcer Prophylaxis in the Intensive Care Unit

Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease

Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys

The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers

The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers

UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD

Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients

Registry for Upper Gastrointestinal Bleeding

Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding