CompletedNot Applicable

The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers

Hong Kong100 participantsStarted 2018-03-16

Plain-language summary

Non-variceal acute gastrointestinal bleeding is a common and potentially life-threatening problem. The conventional treatment of this condition is for esophagogastroduodenoscopy (OGD) for haemostasis. Treatment methods include heater probe, clipping and injection of adrenaline. Recently, a new device called the Over-the-scope clip (OTSC) has been device to treat perforations and bleeding in the gastrointestinal tract. Therefore, the aim of the study is to compare between the treatment outcomes between OTSC and conventional endoscopic haemostatic methods in ulcers that are of high risk for rebleeding.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Actively bleeding peptic ulcers (Forrest Ia, Ib), ulcers with non-bleeding visible vessel or Forrest IIa ulcer (defined as protuberant discoloration, or ulcers with an initial clot and upon irrigation shows a vessel) AND
✓. Ulcer size ≥ 1.5 cm as determined by an opened biopsy forceps;

Exclusion criteria

✕. Patients aged below 18
✕. Peptic ulcer with concomitant perforation
✕. Tumor bleeding
✕. Variceal bleeding
✕. Patients who are pregnant or lactating
✕. Moribund patients or patients with terminal malignancy or end-stage non-malignant conditions, in whom life expectancy is less than 30 days

What they're measuring

The number of cases that develop clinical rebleeding

Timeframe: Within 30 days of therapy

Trial details

NCT IDNCT03160911

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-08-31

View on ClinicalTrials.gov More Ulcer Bleeding trials