Organ Transplant Recipients

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Organ Transplant Recipients trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 28 trials

RecruitingPhase 1

NCT06997471

Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in So…

The goal of this clinical trial is to evaluate the safety and feasibility of inducing hematopoietic mixed chimerism to promote immune tolerance and potentially…

Spain10 participantsStarted 2025-06-10

Treatment: Investigational cellular therapy consisting on a HSCT using a graft enriched in CD34+, depleted of naïve T-lymphocytes and supplemented with memory lymphocytes

RecruitingPhase 2

NCT06552169

REgulatory T Cell Therapy to Achieve Immunosuppression REduction

The goal of this multi-national, multi-center, open-label, randomized Phase 2 trial is to determine the safety and efficacy of administering expanded regulatory…

United States, Taiwan34 participantsStarted 2025-06-13

Treatment: Arm 1: SOC (mTOR + CNI), Arm 2A: TRACT/MONO mTOR

RecruitingPhase 2

NCT05947071

High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD)…

United States312 participantsStarted 2024-09-26

Treatment: Standard Dose Quadrivalent Inactivated Influenza Vaccine, High Dose Quadrivalent Inactivated Influenza Vaccine

RecruitingNot Applicable

NCT01062581

University of Minnesota Transplant Registry

Under Transplant Information Services (TIS), the University of Minnesota Transplant Registry (UMTR) will serve as the repository for core research data.

United States10,000 participantsStarted 1997-03

RecruitingEarly Phase 1

NCT03665675

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

This trial studies the side effects and how well allogeneic cytomegalovirus-specific cytotoxic T lymphocytes (donor cytomegalovirus \[CMV\] specific cytotoxic T…

United States20 participantsStarted 2020-11-07

Treatment: Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes, Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes

RecruitingNot Applicable

NCT07473999

Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection…

Transplantation is one of the most challenging and complex areas of modern medicine. Besides the intrinsic complexity of the surgical and medical procedures, tr…

Italy200 participantsStarted 2019-09-13

Treatment: vaccine prophylaxis

All recent trials (100 shown)

Not Yet RecruitingPhase 4

NCT07570433

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial

Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality following organ transplantation. Cell-mediated immunity plays a crucial role in co…

France, Spain, Switzerland100 participantsStarted 2026-04

Treatment: 50% reduction in the dose of MPA, Switch from MPA to a mammalian target of rapamycin inhibitor (mTORi), together with an adapted dose of tacrolimus

Active — Not RecruitingPhase 4

NCT05557370

Immunogenicity of HPV Vaccine in Transplant Recipients.

To measure levels of HPV antibodies in post-solid-organ transplant recipients who have gotten the HPV9 vaccine.

United States30 participantsStarted 2023-06-01

Treatment: Human Papilloma Virus vaccine (GARDASIL 9)

Organ Transplant Recipients

Trial phase breakdown

Trial status

Actively recruiting — 28 trials

Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in So…

REgulatory T Cell Therapy to Achieve Immunosuppression REduction

High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

University of Minnesota Transplant Registry

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection…

All recent trials (100 shown)

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial

Immunogenicity of HPV Vaccine in Transplant Recipients.

Trial phase breakdown

Trial status

Actively recruiting — 28 trials

Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in So…

REgulatory T Cell Therapy to Achieve Immunosuppression REduction

High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

University of Minnesota Transplant Registry

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection…

All recent trials (100 shown)

HORUS-Cytomegalovirus Open Proof-of-concept Exploratory Trial

Immunogenicity of HPV Vaccine in Transplant Recipients.

Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignanc…

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

"IL-1β Blockade to Prevent Immunothrombosis in Recipients of a Pancreatic Organ"

CMV T Cell Immunity in Pediatric Solid Organ Transplant Recipients

Recombinant Zoster Vaccine in Young Adult Solid Organ Transplant Recipients

Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission

Zoster Vaccine to Enhance Protection Against Zoster in Solid-organ Transplantation

Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy

Rituximab and LMP-Specific T-Cells in Treating Pediatric Solid Organ Recipients With EBV-Positive, CD20-Positive Post-Tr…

Safety and Tolerability of IDO-1 Inhibition in the Prevention of EBV-related Pathology in EBV Negative Kidney Transplant…

High vs. Standard Dose Influenza Vaccine in Adult SOT Recipients

Reduced Immunosuppressive Therapy With or Without Donor White Blood Cells in Treating Patients With Lymphoproliferative…

A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients

HIV-to-HIV Transplant at MGH

Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Prec…

Topical Sirolimus in Chemoprevention of Facial Squamous Cell Carcinomas in Solid Organ Transplant Recipients (SiroSkin)

Exercise Training and Kidney Transplantation