LDL Hyperlipoproteinemia

Clinical trial pipeline · Data from ClinicalTrials.gov

See which LDL Hyperlipoproteinemia trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 17 trials

RecruitingNot Applicable

NCT07447648

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Cor…

This observational, multicenter, retrospective and prospective study aims to evaluate the impact of intensified lipid-lowering therapy including Evinacumab on c…

France, Italy52 participantsStarted 2026-04-30

RecruitingPhase 2

NCT04941599

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

The Investigators will test the hypothesis that 2-HOBA will reduce modification of HDL and LDL and improve HDL function in humans with heterozygous FH. The Inve…

United States72 participantsStarted 2024-02-14

Treatment: 2-Hydroxybenzylamine, Placebo

RecruitingPhase 3

NCT07102628

Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronar…

The purpose of this trial is to learn about the effects of inclisiran in people with serious heart conditions (acute coronary syndromes), when this treatment is…

Australia, Canada, China300 participantsStarted 2025-10-03

Treatment: Placebo, Inclisiran

RecruitingPhase 1

NCT06164730

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial…

United States85 participantsStarted 2024-04-30

Treatment: VERVE-102

RecruitingNot Applicable

NCT06894004

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well un…

United States100 participantsStarted 2025-02-24

Treatment: Ketogenic Diet, Control Diet

RecruitingNot Applicable

NCT04485871

Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease. T2D and heart disease share m…

Canada48 participantsStarted 2019-12-19

Treatment: Omega-3 fatty acids

All recent trials (100 shown)

CompletedNot Applicable

NCT00001154

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal,…

United States759 participantsStarted 1976-09-03

CompletedNot Applicable

NCT05218005

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia

ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coron…

Canada140 participantsStarted 2022-01-01

Treatment: Research-based genetic test for Familial Hypercholesterolemia

LDL Hyperlipoproteinemia

Trial phase breakdown

Trial status

Actively recruiting — 17 trials

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Cor…

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronar…

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

All recent trials (100 shown)

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia

Trial phase breakdown

Trial status

Actively recruiting — 17 trials

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Cor…

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronar…

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

All recent trials (100 shown)

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia

A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Cholesterol Disruption in Combination With the Standard of Care in Patients With Advanced Pancreatic Adenocarcinoma

QLC7401 in the Treatment of Primary Hypercholesterolemia or Mixed Hyperlipidemia With Elevated Low Density Lipoprotein C…

Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygo…

Randomized Controlled Trial of Alert-Based Computerized Decision Support for Optimizing Low-Density Lipoprotein Manageme…

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial Hypercholesterolemia

A Study to Investigate the Effectiveness and Safety of Bempedoic Acid in Patients With Primary Hypercholesterolemia or M…

Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol

VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Disease

Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Ac…

Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies

Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia.

Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III/IV Periodontitis

Pharmacokinetics and Pharmacodynamics Study

Patterns of Inclisiran Use in the Real World: An Analysis of US Databases

Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.

A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Pat…

Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry