Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia (NCT05218005) | Clinical Trial Compass
CompletedNot Applicable
Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia
Canada140 participantsStarted 2022-01-01
Plain-language summary
ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and will impact patient care and outcomes. The study will recruit patients admitted to hospital with an acute coronary syndrome, and research-based genetic testing will be conducted for known FH-causing genetic variants. The results will be returned to the patients' treating physicians. The primary endpoint will be the number of patients with a new diagnosis of definite FH. The secondary endpoints will be the proportion of patients who undergo intensification of lipid-lowering therapy, the lowest LDL cholesterol level achieved, and the proportion of patients reaching guideline recommended lipid targets in the 15 months after the index acute coronary syndrome.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
1. Age \<60 years
AND
2. Admitted to an acute cardiac unit with either:
* A ST elevation myocardial infarction (STEMI), or
* A non-ST elevation myocardial infarction (NSTEMI)
AND
3. Maximum lipid level at the time of admission or during the prior 1 year of
* LDL level ≥4 mmol/L (154 mg/dL) if not on a statin, or
* LDL-C level ≥2.5 mmol/L (96 mg/dL) if on a statin prior to presentation, or
* Non-HDL-C ≥4.6 mmol/L (177 mg/dL)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was specifically focused on identifying new cases of familial hypercholesterolemia in people who came in with a heart attack or acute coronary syndrome — given my situation, is it worth discussing whether I should be formally screened for FH using the same kind of assessment this study used?
2Since this trial has already completed and was about diagnosing FH rather than testing a new drug or treatment, what would a confirmed FH diagnosis actually mean for my treatment plan going forward?
3The trial looked at patients with conditions like NSTEMI and STEMI alongside suspected FH — does my cholesterol history or family history suggest I could have an underlying genetic cause for my high cholesterol that hasn't been tested for yet?
4Because this was a diagnostic study rather than a drug trial, are there established genetic tests or clinical scoring tools — like the ones likely used in this research — that you'd recommend I have done to rule in or rule out familial hypercholesterolemia?
5Since the trial is now complete, has any published data or guidance come out of it that might change how cardiac care units like yours screen and treat patients for FH after a cardiac event?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of patients with a new diagnosis of definite FH