How syphilis is transmitted between sexual partners is unclear. Asymptomatic detection i.e. detection of syphilis bacteria (Tp) from anatomical sites without le…

Australia, China, South Africa480 participantsStarted 2025-12-02

Treatment: No Intervention: Observational Cohort

RecruitingNot Applicable

NCT06069141

Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline

This randomized controlled superiority study will be conducted during 2023-2025. The eligible participants are adult people living with HIV (PLWH) who are newly…

Taiwan688 participantsStarted 2024-01-01

Treatment: Benzathine Penicillin G, Doxycycline Capsule

RecruitingPhase 2

NCT06683638

Daily Doxycycline for Early Syphillis

The goal of this clinical trial is to learn if doxycycline taken as 200mg daily for 14 days is effective to treat early stage syphilis. This is different from h…

United States15 participantsStarted 2025-03-03

Treatment: Doxycycline 200mg daily for 14 days

All recent trials (20 shown)

Active — Not RecruitingPhase 2

NCT05548426

Linezolid for Syphilis Pilot Study

The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.

United States24 participantsStarted 2023-09-28

Treatment: Group B, Linezolid 10d, Group A, Penicillin

TerminatedPhase 4

NCT05980871

Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline

In a prospective study investigating the prevalence of sexually transmitted infections (STIs) among at-risk people living with HIV (PLWH), the prevalence of Chl…

Taiwan109 participantsStarted 2023-03-10

Treatment: Doxycycline, Ceftriaxone

Early Syphilis

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Cefixime Clinical Trial

Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis:…

Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline

Daily Doxycycline for Early Syphillis

All recent trials (20 shown)

Linezolid for Syphilis Pilot Study

Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline

Trial phase breakdown

Trial status

Actively recruiting — 4 trials

Cefixime Clinical Trial

Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis:…

Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline

Daily Doxycycline for Early Syphillis

All recent trials (20 shown)

Linezolid for Syphilis Pilot Study

Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline

Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT

Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)

Alternative Antibiotics for Syphilis

Cefixime Versus Benzathine Penicillin G in Treatment of Early Syphilis

Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Inf…

Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases

Cefixime for Alternative Syphilis Treatment

Counseling and Reminders for Regular HIV and STIs Screening

Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women

One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis

Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin

Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis.

Comparisons of Serologic Response of Early Syphilis

Azithromycin/Bicillin Syphilis