UnknownPhase 4

One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis

China150 participantsStarted 2016-08

Plain-language summary

The purpose of this study is to observe the serological response to 1 or 3 weekly doses of benzathine penicillin G in patients with early syphilis.

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Persons with confirmed early symptomatic syphilis (primary or secondary) or high-titer latent syphilis
✓. A rapid plasma reagin (RPR) test was positive, with a titer were 1:4 or higher. In addition, Treponema pallidum particle agglutination assay and/or fluorescent treponemal antibody absorption test were reactive.

✕.Patients who were pregnancy, known allergy to penicillin, use of antibiotics active against syphilis during the preceding six months for symptomatic cases or during the preceding two years for asymptomatic cases, and concurrent illnesses requiring treatment with antibiotics effective against syphilis. 2. if RPR titers were found to be 1:4 or less or the T. pallidum particle agglutination test was nonreactive, participants were retrospectively excluded from the trial unless primary syphilis was confirmed by the finding of T. pallidum in ulcer exudates on direct immunofluorescence

Rapid plasma reagin titers

Timeframe: up to 9 months after treatment

NCT IDNCT02857959

SponsorJun Li

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-06

Jun Li, M.D.