Azithromycin/Bicillin Syphilis

Inclusion Criteria: * The subject is 18 to 55 years of age. * The subject has signed written informed consent. * The subject has untreated primary \[darkfield or Treponema (T.) pallidum by a rapid, direct, fluorescent antibody darkfield (DFA-TP)\] positive genital ulcers, secondary (based on classical palmar/plantar rash, condylomata lata, mucous patches, etc. or darkfield or DFA-TP positive lesions), or early latent syphilis (e.g., current reactive serologic tests for syphilis (STS), and a documented non-reactive STS or documented sexual exposure to a known early latent, primary or secondary syphilis patient in last 12 months; identification of this sexual contact must occur within 60 days of admission into the study). * The subject has laboratory evidence of syphilis, i.e., reactive serologic test for syphilis (RPR). * The subject is not pregnant, as documented by a negative urine or serum pregnancy test, or lactating. * The subject is willing to have an HIV test, and, participate in HIV counseling and return to the clinic for follow-up treatment. Exclusion Criteria: * The subject does not have reactive serologic tests for syphilis. * The subject has latent syphilis of unknown duration, late latent syphilis or evidence of neurosyphilis. * The subject has a known or suspected allergy to macrolide or azalide antibiotics. * The subject has a known or suspected sexually transmitted disease (STD), other than syphilis requiring treatment with a drug, other than azithromycin, a…