Cocaine-Related Disorders

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Cocaine-Related Disorders trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 20 trials

RecruitingNot Applicable

NCT06552741

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who partic…

United States10,000 participantsStarted 2024-09-04

RecruitingPhase 2

NCT07227948

Repurposing Semaglutide for the Treatment of Cocaine Use Disorder

The purpose of this study is to evaluate semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in combination with cognitive behavioral therapy (CB…

United States75 participantsStarted 2026-01-15

Treatment: Semaglutide, Placebo

RecruitingNot Applicable

NCT05776316

Harm Reduction Services

The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve…

United States200 participantsStarted 2024-11-25

Treatment: Integrated Harm Reduction Intervention (IHRI)

RecruitingNot Applicable

NCT07318480

Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving i…

United States120 participantsStarted 2026-02-25

Treatment: Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training

RecruitingNot Applicable

NCT07071779

Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder

Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide. Although there are…

Switzerland210 participantsStarted 2025-07-23

Treatment: Substance-specific inhibition training, Control training

RecruitingNot Applicable

NCT04927143

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical…

United States600 participantsStarted 2021-09-15

Treatment: App-Based Contingency Management, Sham Control

All recent trials (100 shown)

CompletedEarly Phase 1

NCT05610072

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during…

United States12 participantsStarted 2022-12-15

Treatment: n-acetylcysteine, Hydromorphone

Not Yet RecruitingNot Applicable

NCT07545798

Bright Light Therapy During Inpatient Cocaine Detoxification: a Multicenter Prospective Randomized Clinical Trial

Cocaine is a major psychostimulant used to induce a state of euphoria, improved self-confidence and resistance to fatigue, with suppression of sleep. The progre…

France256 participantsStarted 2026-09-01

Treatment: Medical light therapy device, Medical light therapy device sham

Cocaine-Related Disorders

Trial phase breakdown

Trial status

Actively recruiting — 20 trials

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

Repurposing Semaglutide for the Treatment of Cocaine Use Disorder

Harm Reduction Services

Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

All recent trials (100 shown)

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

Bright Light Therapy During Inpatient Cocaine Detoxification: a Multicenter Prospective Randomized Clinical Trial

Trial phase breakdown

Trial status

Actively recruiting — 20 trials

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

Repurposing Semaglutide for the Treatment of Cocaine Use Disorder

Harm Reduction Services

Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

All recent trials (100 shown)

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

Bright Light Therapy During Inpatient Cocaine Detoxification: a Multicenter Prospective Randomized Clinical Trial

rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder

Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention

AAV8-hCocH for Cocaine Use Disorder

Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder

Contingency Management for Drug Use: Does Age Matter?

Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories

Cariprazine for Comorbid Cocaine and Opioid Use Disorder

Suvorexant for Opioid/Stimulant Co-use

Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)

Rebalancing the Serotonergic System in Cocaine Dependence

Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project

Neurocircuit Strategy to Decrease Cocaine Cue Reactivity

Targeting Drug Memories With Methylphenidate

Psilocybin-facilitated Treatment for Cocaine Use

Multiple Ascending Dose Study of TMP-301 in Healthy Subjects

rTMS for Stimulant Use Disorders

Comparing Efficacy & Safety Of TNX-1300 To Placebo With UC For Treatment Of Acute Cocaine Intoxication In ED Subjects (C…

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder