Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention

Inclusion Criteria: * 18 to 65 years old * meet DSM 5 diagnostic criteria for cocaine use disorder * report recent cocaine use, verified by at least one positive urine drug screen for the cocaine metabolite, benzoylecgonine, during intake * be judged by the medical staff to be psychiatrically stable and physically healthy * for females, be using an effective form of birth control (e.g., barrier, IUD, or sterilization) and not be pregnant as determined by a serum pregnancy test at screening and negative urine pregnancy test at intake prior to first dose of investigational drug (test will be repeated weekly to ensure that female patients do not continue in the study if pregnant) or lactating * be willing to be admitted to a 5-day inpatient detoxification program at The Right Step Houston * be able to understand the consent form and provide written informed consent * be able to provide the names of at least 2 persons who can consistently locate their whereabouts Exclusion Criteria: * have an acute medical or psychiatric disorder that would, in the judgment of the study physician, make participation difficult or unsafe * have suicidal or homicidal ideation that requires immediate attention * have another current (≥ moderate) substance use disorder aside from alcohol, nicotine, or marijuana * have a medical condition contraindicating PIO pharmacotherapy (e.g., drug- or insulin-dependent diabetes, congestive heart failure, edema, clinical significant liver disease, hypoglycemia,…