RecruitingPhase 4

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

United States741 participantsStarted 2023-05-10

Plain-language summary

To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).

Who can participate

Age range65 Years

SexALL

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Inclusion criteria

✓. positive non-invasive functional or anatomic testing suggestive of obstructive coronary artery disease
✓. coronary angiography with stenosis ≥70% in a coronary artery ≥2 mm in diameter or
✓. Invasive coronary angiography with positive physiologic testing in at least one vessel (FFR ≤ 0.80 or iFR ≤0.89)

Exclusion criteria

✕. significant hypotension
✕. high grade AV block
✕. severe symptomatic bradycardia
✕. severe obstructive lung disease
✕. Diagnosis of acute coronary syndrome (ACS) with reduced ejection fraction within past year
✕. Heart failure with reduced ejection fraction (HFrEF) within past year

What they're measuring

Change in Quality of Life assessed using EQ-5D-5L

Timeframe: Baseline and 45 days

Trial details

NCT IDNCT05786417

SponsorYale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-05-30

Contact for this trial

Michael Nanna, MD

(888) 683-0865 livebetter-trial@yale.edu

View on ClinicalTrials.gov More Angina trials