A Study of PEG-somatropin in the Treatment of Children With Idiopathic Short Stature

Exclusion criteria

• ✕. Growth hormone deficiency (GHD) (confirmed by GH stimulation test);
• ✕. Turner syndrome (confirmed by karyotype test of girls);
• ✕. Noonan syndrome (hypertelorism, pectus carinatum, hypophrenia, frequently with skin disease and congenital heart disease, missense mutation of the protein tyrosine phosphatase, non-receptor type 11 (PTPN11) gene on chromosome 12 for half of the patients, for both male and female patients);
• ✕. Laron sydrome (confirmed by IGF-1 generation test);
• ✕. Small for gestational age ( the birth height or weight is below the tenth percentile or 2 SD, with catch-up growth uncompleted at 2 years old).