Wolfram Syndrome

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Wolfram Syndrome trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

RecruitingNot Applicable

NCT02841553

Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study

In this study, the investigators hypothesize that studying monogenic variants with strong effect associated with severe insulin deficiency of Wolfram syndrome w…

United States5,000 participantsStarted 2011-07

RecruitingNot Applicable

NCT03988764

Monogenic Diabetes Misdiagnosed as Type 1

The study has two aims: 1. To (1a) determine the frequency of monogenic diabetes misdiagnosed as type 1 diabetes (T1D) and (2) to define an algorithm for case…

Canada5,000 participantsStarted 2019-09-24

Treatment: None AHT

All recent trials (14 shown)

CompletedPhase 2

NCT03717909

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

This trial aims to investigate the efficacy, safety and tolerability of sodium valproate in the treatment of patients with Wolfram syndrome. 70 paediatric and a…

France, Poland +2 more63 participantsStarted 2018-12-28

Treatment: Sodium Valproate 200Mg E/C Tablet, Sodium Valproate matched placebo

Active — Not RecruitingPhase 2

NCT05676034

AMX0035 in Adult Patients With Wolfram Syndrome

This study is an open label Phase II study to evaluate the safety and efficacy of AMX0035 in adults with Wolfram syndrome.

United States12 participantsStarted 2023-03-03

Treatment: AMX0035

Wolfram Syndrome

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study

Monogenic Diabetes Misdiagnosed as Type 1

All recent trials (14 shown)

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

AMX0035 in Adult Patients With Wolfram Syndrome

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study

Monogenic Diabetes Misdiagnosed as Type 1

All recent trials (14 shown)

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

AMX0035 in Adult Patients With Wolfram Syndrome

Looking for VUS to Confirm Dominant Wolfram-like Syndrome Instead of Recessive Wolfram Syndrome

Does Recessive Optic Atrophy Due to WFS1 Exist?

Mechanisms of Fecal Incontinence in Wolfram Syndrome

I-Tracking Neurodegeneration in Early Wolfram Syndrome

A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome

Tirzepatide Monotherapy in Patients With Wolfram Syndrome Type 1

Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome

GLP Analogs for Diabetes in Wolfram Syndrome Patients

Tracking Neurodegeneration in Early Wolfram Syndrome

Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy