Tobacco Cigarette Smoking

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Tobacco Cigarette Smoking trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 40 trials

RecruitingPhase 2

NCT05937854

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high…

United States126 participantsStarted 2024-04-01

Treatment: Tadalafil, Placebo

RecruitingNot Applicable

NCT07199517

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of samplin…

United States472 participantsStarted 2026-01-12

Treatment: HRP Sampling period, NPL Sampling period

RecruitingEarly Phase 1

NCT07007195

Smart Olfaction App to Reduce Relapse

The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimula…

United States132 participantsStarted 2026-04-22

Treatment: Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device

RecruitingNot Applicable

NCT07443631

Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants

This is a randomized, controlled, open-label, 6 parallel arms study to assess reduced exposure of biomarkers of exposure (BoE) of selected HPHC in smokers switc…

United Kingdom108 participantsStarted 2026-02-19

Treatment: THS1 (TP18 variant 1), THS2 (TP18 variant 2)

RecruitingPhase 2

NCT06296849

Dyadic Financial Incentive Treatments for Dual Smoker Couples

Smokers partnered with other smokers (i.e., dual-smoker couples) represent \~2/3 of all smokers. Dual-smoker couples (DSCs) are less likely to try to quit smoki…

United States900 participantsStarted 2024-01-18

Treatment: Financial Incentive Treatment (FIT)

RecruitingPhase 4

NCT05587361

Beta-Adrenergic Modulation of Drug Cue Reactivity

This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in c…

United States80 participantsStarted 2024-11-26

Treatment: Propranolol, Nicotine Patch

All recent trials (100 shown)

CompletedNot Applicable

NCT05385055

Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to…

This is a cross-sectional 3-group study with subjects enrolled and matched by region (Asia, Europe), age, sex, and average daily product consumption over the la…

Bulgaria, Czechia974 participantsStarted 2022-06-13

Treatment: THS use, Cigarette smoking

By InvitationNot Applicable

NCT07039292

Clinical Alternatives for Reducing Harm Using E-cigarettes

For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even…

United States208 participantsStarted 2025-08-25

Treatment: Harm Reduction (E-cigarette switching), Standard of Care

Tobacco Cigarette Smoking

Trial phase breakdown

Trial status

Actively recruiting — 40 trials

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Smart Olfaction App to Reduce Relapse

Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants

Dyadic Financial Incentive Treatments for Dual Smoker Couples

Beta-Adrenergic Modulation of Drug Cue Reactivity

All recent trials (100 shown)

Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to…

Clinical Alternatives for Reducing Harm Using E-cigarettes

Trial phase breakdown

Trial status

Actively recruiting — 40 trials

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Smart Olfaction App to Reduce Relapse

Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants

Dyadic Financial Incentive Treatments for Dual Smoker Couples

Beta-Adrenergic Modulation of Drug Cue Reactivity

All recent trials (100 shown)

Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to…

Clinical Alternatives for Reducing Harm Using E-cigarettes

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

Testing a School-Based E-cigarette, Tobacco, and Betel (Areca) Nut Use Prevention Curriculum for Guam Youths

Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes

Episodic Future Thinking, Loss Aversion and Cigarette Smoking

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis

Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study

Varenicline for Smoking Reduction in Veterans Not Ready To Quit

Varenicline and Combined NRT for Smoking Cessation

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study

Development of UP2UTobacco for High School Youth

Examination of Low Wattage and High Wattage E-Cigarettes

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks

Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)

PASCAL Feasibility Study

Effectiveness of Brief Smoking Cessation Counselling in Pre-Anaesthesia Assessment Clinic