Not Yet RecruitingNot Applicable

Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

60 participantsStarted 2026-06-30

Plain-language summary

This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily. Secondary objectives include assessing preliminary efficacy on cessation and examining cue reactivity. Participants will be randomized to CBT only or CBT + cue-based treatment, with assessments at baseline, end-of-treatment, 6 months, and 12 months.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 * Able to read and understand English or Spanish * Smoke 1-10 cigarettes/day on at least 4 days of the past two weeks for the last year * Willing to try quitting in next 30 days * Access to cell phone with texting capabilities Exclusion Criteria: * Current participation in another smoking cessation study * Unable to provide consent * Refusal to abstain from e-cigarettes or other tobacco products * Use of medications affecting smoking cessation (e.g., Chantix, Wellbutrin)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Feasibility as measured by the number of participants who are recruited and randomized

Timeframe: During the recruitment period (up to 9 months)

Feasibility as measured by the number of participants who respond to pre-quit real-time data collection

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who take pictures of smoking/craving situations

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who complete all CBT (cognitive behavioral therapy) sessions

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who complete all cue-based treatment sessions

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who respond to EMA text based assessments

Timeframe: End of treatment (up to 12 months)

Trial details

NCT IDNCT07425119

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-01

Contact for this trial

Laura Fish, PhD

919-681-3820 laura.fish@duke.edu

View on ClinicalTrials.gov More Tobacco Use Disorder trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Feasibility as measured by the number of participants who are recruited and randomized

Timeframe: During the recruitment period (up to 9 months)

Feasibility as measured by the number of participants who respond to pre-quit real-time data collection

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who take pictures of smoking/craving situations

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who complete all CBT (cognitive behavioral therapy) sessions

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who complete all cue-based treatment sessions

Timeframe: End of treatment (up to 12 months)

Feasibility as measured by the number of participants who respond to EMA text based assessments

Timeframe: End of treatment (up to 12 months)