Systemic Fungal Infections

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Systemic Fungal Infections trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 35 trials

RecruitingPhase 1/2

NCT06749457

A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Dis…

The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I)…

United States231 participantsStarted 2024-12-30

Treatment: AZD7760, Placebo

RecruitingPhase 4

NCT06726395

Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia

The goal of this study is to investigate if benzylpenicillin is a better treatment option than cloxacillin in patients with penicillin-susceptible Staphylococcu…

Sweden420 participantsStarted 2025-03-10

Treatment: Penicillin G_1200mg, cloxacillin

RecruitingPhase 3

NCT05421858

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invas…

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidemi…

United States450 participantsStarted 2024-12-11

Treatment: Fosmanogepix, Fosmanogepix

RecruitingPhase 4

NCT05770622

Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)

A challenge to intermittent vancomycin dosing in young infants is the avoidable delay caused by the need to wait until steady state (i.e. when the drug concentr…

Australia40 participantsStarted 2024-11-10

Treatment: First-dose trough dose adjustment calculator - using early TDM (first-dose trough) to determine an early dose adjustment if the predicted steady-state trough is outside of target range (10-20mg/L)

RecruitingPhase 1

NCT06508463

Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus (VSV) carrying the human (h) sodium iodide symporter (NIS) a…

United States21 participantsStarted 2024-01-05

Treatment: Biopsy, Biospecimen Collection

RecruitingPhase 1

NCT03017820

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in…

This phase I trial studies the best dose and side effects of the VSV-hIFNβ-NIS vaccine with or without cyclophosphamide and combinations of ipilimumab, nivoluma…

United States127 participantsStarted 2017-04-04

Treatment: Biopsy Procedure, Biospecimen Collection

All recent trials (100 shown)

CompletedNot Applicable

NCT04821661

T2 and SeptiCyte RAPID Duration Project

Infection with bacteria and other germs in the blood can be deadly. How long germs stay in the blood is important for two reasons. The first is that if they sta…

Australia102 participantsStarted 2022-01-11

TerminatedPhase 3

NCT05238116

Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory…

To assess the safety and efficacy of nebulized PC945 in combination with systemic antifungal therapy for the treatment of refractory IPA

United States85 participantsStarted 2022-06-14

Treatment: PC945, Placebo

Systemic Fungal Infections

Trial phase breakdown

Trial status

Actively recruiting — 35 trials

A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Dis…

Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invas…

Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)

Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in…

All recent trials (100 shown)

T2 and SeptiCyte RAPID Duration Project

Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory…

Trial phase breakdown

Trial status

Actively recruiting — 35 trials

A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Dis…

Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invas…

Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)

Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in…

All recent trials (100 shown)

T2 and SeptiCyte RAPID Duration Project

Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory…

Preventing Catheter-related Bacteremia When Administering Injectable Medications in Premature Infants.

A Follow-up Trial of GBS-NN/NN2 Vaccine in Healthy Pregnant Women

Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Unde…

Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia

National Study on Listeriosis and Listeria

Study Evaluating Safety, Tolerability, and Efficacy of Intravenous AP-SA02 in Subjects With S. Aureus Bacteremia

Observational Study of Raxibacumab in Sporadic Cases of Systemic Anthrax

Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants

The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospital…

Non-Conventional Microbiological Methods in the Diagnosis of Candidemia

Phylogenetic Characteristics of Different Candida Species and Their Impact on the Clinical Picture of Patients With Inva…

Safety & Efficacy of True Human Antibody, 514G3, in Staphylococcus Aureus Bacteremia Hospitalized Subjects.

Observational Study Evaluating Clinical Benefit and Safety of AIGIV (ANTHRASIL®) in Patients With Systemic Anthrax

Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignanci…

Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins

Efficacy and Safety of 7 Versus 14 Days of Antibiotic Treatment for Pseudomonas Aeruginosa Bacteraemia