Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin

Inclusion Criteria: * Age 65 years or older * Receive systemic antibiotics in the last 90 days * Hospitalized anywhere in the last 90 days * History of C diff colonization without history of C diff colitis (infection) * Provide informed consent * Read and understand the English language * Not current taking probiotics * Lack of allergy or contraindications to receive vancomycin * Ability to take oral medications * Not receiving medications that can be used to treat or prevent C diff Exclusion Criteria: * Age 64 years or younger * Has not received systemic antibiotics in the last 90 days * Has not been hospitalized in the last 90 days * History of C diff colonization with a history of C diff colitis (infection) * Not provided informed consent * Cannot read and understand the English language * Currently receiving probiotics * Allergy or contraindications to receive vancomycin * Unable to take oral medications * Receiving medications that can be used to treat or prevent C diff