Sclerosis

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Sclerosis trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 48 trials

RecruitingNot Applicable

NCT05644522

Nomad P-KAFO Study

The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that h…

United States36 participantsStarted 2024-03-01

Treatment: Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)

RecruitingPhase 1/2

NCT07473154

Controlling Hyperactive Immunity With Long-lived Lymphocytes

This study is a Phase 1/2, open-label clinical trial to test an experimental treatment called QEL-005 in adults with two autoimmune conditions: diffuse cutaneou…

United Kingdom16 participantsStarted 2026-04

Treatment: QEL-005

RecruitingPhase 3

NCT06700343

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

The main objectives of the study are to demonstrate pharmacokinetics (PK) similarity between ABP 692 and Ocrelizumab (US), and ABP 692 and Ocrelizumab (EU), and…

United States444 participantsStarted 2025-01-13

Treatment: Ocrelizumab (US), Ocrelizumab (EU)

RecruitingNot Applicable

NCT07295990

Tongue-strengthening Exercises in People With ALS.

This study is testing a tongue exercise program for people living with ALS to see if it can help support speech and swallowing. All participants will receive th…

United States20 participantsStarted 2026-05-01

Treatment: Isometric Lingual Strength Exercises

RecruitingNot Applicable

NCT04603196

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which…

United States800 participantsStarted 2019-06-20

RecruitingNot Applicable

NCT07543367

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

United States10 participantsStarted 2026-04

Treatment: Stentrode

All recent trials (100 shown)

CompletedNot Applicable

NCT07566988

A Real-world Study Comparing the Effectiveness of Ofatumumab and Ocrelizumab Treatment in Multiple Sclerosis Patients

The aim of this study was to compare the effectiveness and economic burden of ofatumumab (OMB) and ocrelizumab (OCR) treatment in multiple sclerosis (MS) patien…

United States2,604 participantsStarted 2024-10-25

TerminatedNot Applicable

NCT05828901

Predicting Disease Activity and Rebound Risk in MS Patients Treated With Sphingosine-1-phosphate Receptor Modulators (S1…

Sphingosine 1-Phosphate (S1P) receptor modulators (S1PRMs) are part of the evolving treatment landscape of Multiple Sclerosis (MS) immunotherapies. They target…

Switzerland23 participantsStarted 2023-03-27

Treatment: S1PR analysis on immune cells

Sclerosis

Trial phase breakdown

Trial status

Actively recruiting — 48 trials

Nomad P-KAFO Study

Controlling Hyperactive Immunity With Long-lived Lymphocytes

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

Tongue-strengthening Exercises in People With ALS.

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

All recent trials (100 shown)

A Real-world Study Comparing the Effectiveness of Ofatumumab and Ocrelizumab Treatment in Multiple Sclerosis Patients

Predicting Disease Activity and Rebound Risk in MS Patients Treated With Sphingosine-1-phosphate Receptor Modulators (S1…

Trial phase breakdown

Trial status

Actively recruiting — 48 trials

Nomad P-KAFO Study

Controlling Hyperactive Immunity With Long-lived Lymphocytes

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

Tongue-strengthening Exercises in People With ALS.

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

All recent trials (100 shown)

A Real-world Study Comparing the Effectiveness of Ofatumumab and Ocrelizumab Treatment in Multiple Sclerosis Patients

Predicting Disease Activity and Rebound Risk in MS Patients Treated With Sphingosine-1-phosphate Receptor Modulators (S1…

The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple S…

Role of Circulating Cytotoxic Lymphocytes in Endothelial Cell Injury in Systemic Sclerosis

Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS

Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE)

Novel MRI Biomarkers for Monitoring Disease Progression in ALS

Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

Glymphatic MRI in Clinically Isolated Syndrome

Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple Sclerosis

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene M…

Single Arm Trial Identifying Barriers and Facilitators to Mindfulness Practice

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Alter-Ego as an Assistive Robotic Device.

Gait in Rare Diseases

Clemastine Fumarate as Remyelinating Treatment in Internuclear Ophthalmoparesis and Multiple Sclerosis

Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment

Therapeutic Approach of Repeated Transient Blood-brain Barrier Opening in Amyotrophic Lateral Sclerosis.

The Effect of DNS-Based Training Combined With PFMT on LUTS and Pelvic Floor Functions in Women With MS

A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis