Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, characterized by inflammation, demyelination, and axonal degeneration, and primarily affects young adults. Muscle weakness, sensory disturbances, spasticity, pain, visual impairment, ataxia, fatigue, cognitive dysfunction, and respiratory complications are among the most commonly reported symptoms in individuals with MS. Although inspiratory muscle training has been shown to have beneficial effects in individuals with MS, the effects of different inspiratory muscle training intensities on respiratory muscle strength and pulmonary function have not been sufficiently investigated. The primary aim of this study is to investigate the effectiveness and clinical feasibility of high-intensity interval inspiratory muscle training in individuals with MS. The secondary aim is to compare the effects of high-intensity interval inspiratory muscle training, low-intensity inspiratory muscle training, and conventional rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, lower extremity functional muscle strength, balance, fatigue, dysphagia severity, sleep quality, and quality of life in individuals with MS. Participants will be randomly assigned to one of three groups: a high-intensity interval inspiratory muscle training group, a low-intensity inspiratory muscle training group, or a conventional rehabilitation group. All three groups will receive conventional rehabilitation, while the inspiratory muscle training groups will additionally receive their respective inspiratory muscle training programs. This study aims to be the first randomized controlled trial to evaluate the effects of high-intensity interval inspiratory muscle training in individuals with MS.
Age range
18 Years – 65 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Maximal inspiratory pressure (MIP)
Timeframe: From baseline to the end of the intervention at 8 weeks
Maximal expiratory pressure (MEP)
Timeframe: From baseline to the end of the intervention at 8 weeks
Forced Vital Capacity (FVC)
Timeframe: From baseline to the end of the intervention at 8 weeks
Forced Expiratory Volume (FEV1)
Timeframe: From baseline to the end of the intervention at 8 weeks
Tiffeneau Index (FEV1/FVC)
Timeframe: From baseline to the end of the intervention at 8 weeks
Peak Expiratory Flow (PEF)
Timeframe: From baseline to the end of the intervention at 8 weeks
Cough strength
Timeframe: From baseline to the end of the intervention at 8 weeks