Overt Hepatic Encephalopathy

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Overt Hepatic Encephalopathy trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

RecruitingNot Applicable

NCT06425380

Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy

This research is studying how a food product (resistant potato starch) which is a dietary supplement made from potato starch affects the gut bacteria of people…

United States11 participantsStarted 2024-07-12

Treatment: Resistant Potato Starch

RecruitingNot Applicable

NCT06483737

Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)

Hepatic encephalopathy (HE), a severe complication of decompensated cirrhosis, is characterized as neurocognitive dysfunction. Emerging evidence suggests the po…

China174 participantsStarted 2025-06-24

Treatment: Human albumin infusion at a modified dosage, Human albumin infusion at a routine dosage

All recent trials (28 shown)

CompletedPhase 3

NCT02016196

Rifaximin vs Placebo for the Prevention of Encephalopathy in Patients Treated by TIPS

TIPS has been used for 20 years, as a means of reducing portal pressure in patients with cirrhosis and portal hypertension related complications. TIPS proved mo…

France211 participantsStarted 2013-09

Treatment: Rifaximin, placebo

TerminatedPhase 2

NCT06987968

A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With…

A Phase 2, Randomized, Controlled, Open-Label, Adaptive Dose Design, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Two Differ…

United States, France, Georgia3 participantsStarted 2025-08-25

Treatment: VS-01 on top of SOC (Active Treatment Group), SOC

Overt Hepatic Encephalopathy

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy

Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)

All recent trials (28 shown)

Rifaximin vs Placebo for the Prevention of Encephalopathy in Patients Treated by TIPS

A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With…

Trial phase breakdown

Trial status

Actively recruiting — 2 trials

Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy

Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)

All recent trials (28 shown)

Rifaximin vs Placebo for the Prevention of Encephalopathy in Patients Treated by TIPS

A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With…

UDCA to Prevent Post-TIPS Hepatic Encephalopathy

A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy.

Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)

A Study of MHE in Patients With Liver Diseases

Prospective Cohort Study of Complications and Outcomes in Cirrhosis

Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopath…

Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy

Rifaximin Soluble Solid Dispersion (SSD) Tablets Plus Lactulose for the Treatment of Overt Hepatic Encephalopathy (OHE)

Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy

Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF

Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy

Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients

MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP…

Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE

The Safety/Efficacy of Rifaximin With/Without Lactulose in Participants With A History of Recurrent Hepatic Encephalopat…

PEG3350 in ACLF With Hepatic Encephalopathy

To Compare Efficacy and Safety of Lactulose Versus Polyethylene Glycol for Treatment of Overt Hepatic Encephalopathy in…