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Prospective Cohort Study of Complications and Outcomes in Cirrhosis

China660 participantsStarted 2024-01-01

Plain-language summary

This is a multi-center, nested cohort study intended to investigate the prevalence, risk factors, and outcomes of complications in patients with acutely decompensated cirrhosis, especially focused on Cytomegalovirus (CMV) reactivation, bacterial infections, hepatic encephalopathy, and Hepatorenal syndrome. Patients diagnosed with acutely decompensated cirrhosis were enrolled. Upon enrollment, detailed baseline data were collected and samples were harvested. Complications were assessed during hospitalization. Post-discharge follow-up was conducted through telephonic interviews at Day 30 and Day 90.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Informed written consent * Age between 18 years and 80 years * Cirrhosis based on liver histology or a combination of characteristic clinical, biochemical, and imaging features * Complications of decompensated cirrhosis (ascites, gastrointestinal bleeding and hepatic encephalopathy) Exclusion Criteria: * Malignancy * Acquired immune deficiency syndrome * Received immunosuppressive drugs for non-hepatic reasons * Received organ transplantations

What they're measuring

Incidence of CMV reactivation

Timeframe: From enrollment to 90 days

Incidence of hepatic encephalopathy

Timeframe: From enrollment to 90 days

Trial details

NCT IDNCT06374511

SponsorNanfang Hospital, Southern Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-04-04

Contact for this trial

Jinjun Chen

13902246336 chjj@smu.edu.cn

View on ClinicalTrials.gov More Decompensated Cirrhosis trials